CRISPR / Cas9 method: The cutting edge technique

introduction This simple and fast method of changing genes has revolutionized the scientific world. The CRISPR / Cas9 method allows very fast and specific genome editing. This technique has already been used successfully in many model organisms (yeast, plant, zebrafish, Drosophila, nematode and mouse) and also works very well in human cell lines. As a result, it…

By Bertha Cooper July 21, 2020 Off

What is oxidative stress?

Oxidative stress in a living organism is a chemical state in which oxidative species overcome antioxidative systems due to an imbalance between the two parts. The oxidizing species, among which the free radicals stand out, perform important functions such as the elimination of pathogenic bacteria, the regulation of arterial pressure and the transmission of signals. If free…

By Bertha Cooper July 21, 2020 Off

Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.

OBJECTIVETo consider whether or not penetration of a mix routine into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is related to decrease cerebrospinal fluid (CSF) viral load. METHODSData had been analyzed from 467 contributors who had been human immunodeficiency virus (HIV) seropositive and who reported antiretroviral (ARV) drug use.…

By Bertha Cooper May 15, 2020 Off

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

A pathological hallmark of Alzheimer’s illness is an accumulation of insoluble plaque containing the amyloid-beta peptide of 40-42 amino acid residues. Prefibrillar, soluble oligomers of amyloid-beta have been acknowledged to be early and key intermediates in Alzheimer’s-disease-related synaptic dysfunction. At nanomolar concentrations, soluble amyloid-beta oligomers block hippocampal long-term potentiation, trigger dendritic backbone retraction from pyramidal cells and…

By Bertha Cooper May 15, 2020 Off

Morphological Characteristic Regulation of Ligninolytic Enzyme Produced by Trametes polyzona.

A newly remoted white rot fungal pressure KU-RNW027 was recognized as Trametes polyzona, primarily based on an evaluation of its morphological traits and phylogenetic information. Aeration and fungal morphology have been essential components which drove pressure KU-RNW027 to secrete two completely different ligninolytic enzymes as manganese peroxidase (MnP) and laccase. Highest actions of MnP and laccase have…

By Bertha Cooper May 15, 2020 Off

Lab Promotions

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By Bertha Cooper March 29, 2020 Off

Biotechnology

ChemHunting distributes life science tools and chemicals:   01. Cell culture Plasticwares02. Instruments03. Proteomics-related04. Immunology-related05. Filtration06. Cell culture media & reagents07. Molecular Biology-related 

By Bertha Cooper March 29, 2020 Off