Category: Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

The Impact of Iodine Exposure in Excess on Hormonal Aspects and Hemato-Biochemical Profile in Rats

Excessive publicity of iodine over a time is well-known to trigger thyroid dysfunction, which can be adopted by totally different results on physique organs. The current examine aimed for instance the impacts of publicity of rats to extra iodine (above the tolerable vary) and the reversibility of any detrimental impacts on hormonal profile associated to…

By Bertha Cooper April 6, 2021 Off

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

A pathological hallmark of Alzheimer’s illness is an accumulation of insoluble plaque containing the amyloid-beta peptide of 40-42 amino acid residues. Prefibrillar, soluble oligomers of amyloid-beta have been acknowledged to be early and key intermediates in Alzheimer’s-disease-related synaptic dysfunction. At nanomolar concentrations, soluble amyloid-beta oligomers block hippocampal long-term potentiation, trigger dendritic backbone retraction from pyramidal cells and…

By Bertha Cooper May 15, 2020 Off