What is oxidative stress?

What is oxidative stress?

July 21, 2020 Off By Bertha Cooper

Oxidative stress in a living organism is a chemical state in which oxidative species overcome antioxidative systems due to an imbalance between the two parts. The oxidizing species, among which the free radicals stand out, perform important functions such as the elimination of pathogenic bacteria, the regulation of arterial pressure and the transmission of signals. If free radicals are present in excess, they can change the normal function of the molecules of vital organs, which leads to cell and tissue damage.If this damage is not repaired immediately, they promote or accelerate the occurrence of very common forms of disease such as atherosclerosis, stroke , Parkinson’s, Alzheimer’s disease, diabetes, certain cancers and other pathologies.

In addition, an increase in free radicals promotes the premature aging of the organism. The causes of oxidative stress include pollution, poor nutrition, lack of exercise, chronic medication, untreated inflammation, cigarette smoking and alcohol abuse.

Measurement of oxidative stress

Because oxidative stress has no specific clinical manifestation, it can only be identified if the clinician suspects its presence and suggests that the patient go to a laboratory and have a blood test done.

Depending on the clinical situation, he may suggest that the patient request one or more Panel Carratelli tests. For a comprehensive evaluation of the oxidative equilibrium, the d-ROMs test for evaluating the pro-oxidative status in conjunction with one of the parameters relating to the antioxidative potential is required (BAP test, OXY adsorbent test, -SHp test and anti-ROMs test).

The state of oxidative stress is signaled by an increase in the d-ROMs values ​​and / or a decrease in the BAP test or OXY adsorbent test or SHp test or anti-ROMs test values.

The results of these investigations lead to an extremely precise and reliable clinical diagnosis of oxidative stress, whereby the two opposing parameters (pro-oxidative and antioxidative) can be assessed individually. This enables a real-time picture of the causes of oxidative stress, the increased production of free radicals or a reduced capacity of the antioxidative barrier. Monitoring of antioxidant therapy can be done on a solid basis and not on an empirical idea.

Who should measure oxidative stress?

Panel Carratelli tests are useful as preventive diagnostics because they provide an indication of the general well-being of the organism. For this reason, every person should undergo an oxidative stress test, even if they are in good health, since oxidative stress does not produce any specific clinical manifestations.
The tests are particularly recommended if it is a person who …

– is exposed to pro-oxidative factors (e.g. wrong lifestyle, pollutants in the workplace, etc …)

– has to undergo specific treatments (e.g. dialysis, bypass, organ transplant, pill, radiation therapy, chemotherapy, etc.)

– suffer from chronic degenerative diseases (e.g. diabetes, atherosclerosis, cancer, dementia, rheumatic arthritis, etc.)

How to fight oxidative stress

The treatment of oxidative stress requires the identification of the causes and the decisive mechanisms. When there is an increased production of free radicals, it is necessary to identify the primary source of metabolism responsible and try to keep it under control (e.g. to reduce inflammation, improve tissue circulation, reduce toxin load, etc.). ). On the other hand, if the antioxidant defenses are reduced, we need to restore them through the most appropriate antioxidant diet, regular and not excessive physical activity, the reduction of smoking, alcohol and stress. If the lack of antioxidants cannot be restored through nutritional interventions, it is possible

IVD | Kits for in vitro diagnostics

Item No.testAnalytesize
Pro oxidation status
MC001d-ROMs testReactive oxygen
Antioxidant status
MC436BAP testBiological antioxidant potential1x50mL
MC434OXY absorbent testTotal antioxidant barrier2x25mL
MC432-SHp testPlasma thiol groups1x50mL

IVD | FREE systems and related kits

FREE systems
FREE Carpe DiemPhotometer with integrated mini centrifuge, pipette and accessories
FREE duoPhotometer with double measuring cell, integrated mini centrifuge, pipette and accessories
FREE Systems related kits
Item No.testAnalytesize
Pro oxidation status
MC013 / FREEd-ROMs testReactive oxygen metabolites (hydroperoxides)40 det.
Antioxidant status
MC436 / FREEBAP testBiological antioxidant potential40 det.
MC434 / FREEOXY absorbent testTotal antioxidant barrier50 det.
MC432 / FREE-SHp testPlasma thiol groups40 det.

FRUO | Kits for in vitro diagnostics

Item No.testAnalytesize
Pro oxidation status
MC045LP CHOLOX testLipoperoxides50 det.
MC042MAc testOrganic acids40 det.
MC039LP sperm testLipoperoxides40 det.
MC040LipotissLipoperoxides50 det.